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There are several different Production Runes. They are used in, you guessed it, the production of finished goods via Crafting.
Whenever a mobs loot table says "Production Rune", it can randomly be any of the following runes:
- Activate Rune - Cooking
- Blend Rune - Alchemy
- Disenchant Rune - Tailoring
- Frost Rune - Blacksmithing
- Link Rune - Carpentry
- Purify Rune - Armorcrafting
Some mobs always drop the same Production Rune, when they do drop one, and in those cases where we are sure of this we may list the rune in his Known Drops information.